Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report

Abstract Background Glioblastoma multiform (GBM), a malignant brain tumour, has a very often poor prognosis. The therapeutic approach is represented by surgery followed by radiotherapy and chemotherapy. Hypoxia is a factor that causes a reduction of both radiotherapy and chemotherapy effectiveness i...

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Main Authors: Vincenzo Gangemi, Chiara Mignogna, Giusy Guzzi, Angelo Lavano, Salvatore Bongarzone, Giuseppe Lucio Cascini, Umberto Sabatini
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Cancer
Online Access:https://doi.org/10.1186/s12885-019-6368-8
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spelling doaj-1c09c3f722534533a02715bad51cea5a2020-12-06T12:53:44ZengBMCBMC Cancer1471-24072019-12-011911410.1186/s12885-019-6368-8Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case reportVincenzo Gangemi0Chiara Mignogna1Giusy Guzzi2Angelo Lavano3Salvatore Bongarzone4Giuseppe Lucio Cascini5Umberto Sabatini6Department of Diagnostic Imaging, Nuclear Medicine Unit, Magna Graecia University of CatanzaroHealth Science - Interdipartimental Service Center, University “Magna Graecia” of Catanzaro Medical SchoolDepartment of Neurosurgery, Magna Graecia University of CatanzaroDepartment of Neurosurgery, Magna Graecia University of CatanzaroSchool of Biomedical Engineering & Imaging Sciences, King’s College London, King’s Health Partners, St Thomas’ HospitalDepartment of Diagnostic Imaging, Nuclear Medicine Unit, Magna Graecia University of CatanzaroNeuroradiology Unit, University “Magna Graecia”Abstract Background Glioblastoma multiform (GBM), a malignant brain tumour, has a very often poor prognosis. The therapeutic approach is represented by surgery followed by radiotherapy and chemotherapy. Hypoxia is a factor that causes a reduction of both radiotherapy and chemotherapy effectiveness in GBM and other cancers. Through the use of [64Cu][Cu(ATSM)], a hypoxia-targeting positron emission tomography (PET) radiotracer, is possible to identify the presence of hypoxic areas within a lesion and therefore modulate the therapeutic approach according to the findings. Case presentation In this case report, we observed an increase of radiotracer uptake from early acquisition to late acquisition in hypoxia sites and high correlation between [64Cu][Cu(ATSM) PET/CT results and expression of the hypoxia marker HIF-1α. Conclusions [64Cu][Cu(ATSM) PET/CT represents a valid opportunity to reveal in vivo hypoxic areas in GBM lesion which can guide clinicians on selecting GMB patient’s therapeutic scheme.https://doi.org/10.1186/s12885-019-6368-8
collection DOAJ
language English
format Article
sources DOAJ
author Vincenzo Gangemi
Chiara Mignogna
Giusy Guzzi
Angelo Lavano
Salvatore Bongarzone
Giuseppe Lucio Cascini
Umberto Sabatini
spellingShingle Vincenzo Gangemi
Chiara Mignogna
Giusy Guzzi
Angelo Lavano
Salvatore Bongarzone
Giuseppe Lucio Cascini
Umberto Sabatini
Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report
BMC Cancer
author_facet Vincenzo Gangemi
Chiara Mignogna
Giusy Guzzi
Angelo Lavano
Salvatore Bongarzone
Giuseppe Lucio Cascini
Umberto Sabatini
author_sort Vincenzo Gangemi
title Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report
title_short Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report
title_full Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report
title_fullStr Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report
title_full_unstemmed Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report
title_sort impact of [64cu][cu(atsm)] pet/ct in the evaluation of hypoxia in a patient with glioblastoma: a case report
publisher BMC
series BMC Cancer
issn 1471-2407
publishDate 2019-12-01
description Abstract Background Glioblastoma multiform (GBM), a malignant brain tumour, has a very often poor prognosis. The therapeutic approach is represented by surgery followed by radiotherapy and chemotherapy. Hypoxia is a factor that causes a reduction of both radiotherapy and chemotherapy effectiveness in GBM and other cancers. Through the use of [64Cu][Cu(ATSM)], a hypoxia-targeting positron emission tomography (PET) radiotracer, is possible to identify the presence of hypoxic areas within a lesion and therefore modulate the therapeutic approach according to the findings. Case presentation In this case report, we observed an increase of radiotracer uptake from early acquisition to late acquisition in hypoxia sites and high correlation between [64Cu][Cu(ATSM) PET/CT results and expression of the hypoxia marker HIF-1α. Conclusions [64Cu][Cu(ATSM) PET/CT represents a valid opportunity to reveal in vivo hypoxic areas in GBM lesion which can guide clinicians on selecting GMB patient’s therapeutic scheme.
url https://doi.org/10.1186/s12885-019-6368-8
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