Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report
Abstract Background Glioblastoma multiform (GBM), a malignant brain tumour, has a very often poor prognosis. The therapeutic approach is represented by surgery followed by radiotherapy and chemotherapy. Hypoxia is a factor that causes a reduction of both radiotherapy and chemotherapy effectiveness i...
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doaj-1c09c3f722534533a02715bad51cea5a2020-12-06T12:53:44ZengBMCBMC Cancer1471-24072019-12-011911410.1186/s12885-019-6368-8Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case reportVincenzo Gangemi0Chiara Mignogna1Giusy Guzzi2Angelo Lavano3Salvatore Bongarzone4Giuseppe Lucio Cascini5Umberto Sabatini6Department of Diagnostic Imaging, Nuclear Medicine Unit, Magna Graecia University of CatanzaroHealth Science - Interdipartimental Service Center, University “Magna Graecia” of Catanzaro Medical SchoolDepartment of Neurosurgery, Magna Graecia University of CatanzaroDepartment of Neurosurgery, Magna Graecia University of CatanzaroSchool of Biomedical Engineering & Imaging Sciences, King’s College London, King’s Health Partners, St Thomas’ HospitalDepartment of Diagnostic Imaging, Nuclear Medicine Unit, Magna Graecia University of CatanzaroNeuroradiology Unit, University “Magna Graecia”Abstract Background Glioblastoma multiform (GBM), a malignant brain tumour, has a very often poor prognosis. The therapeutic approach is represented by surgery followed by radiotherapy and chemotherapy. Hypoxia is a factor that causes a reduction of both radiotherapy and chemotherapy effectiveness in GBM and other cancers. Through the use of [64Cu][Cu(ATSM)], a hypoxia-targeting positron emission tomography (PET) radiotracer, is possible to identify the presence of hypoxic areas within a lesion and therefore modulate the therapeutic approach according to the findings. Case presentation In this case report, we observed an increase of radiotracer uptake from early acquisition to late acquisition in hypoxia sites and high correlation between [64Cu][Cu(ATSM) PET/CT results and expression of the hypoxia marker HIF-1α. Conclusions [64Cu][Cu(ATSM) PET/CT represents a valid opportunity to reveal in vivo hypoxic areas in GBM lesion which can guide clinicians on selecting GMB patient’s therapeutic scheme.https://doi.org/10.1186/s12885-019-6368-8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vincenzo Gangemi Chiara Mignogna Giusy Guzzi Angelo Lavano Salvatore Bongarzone Giuseppe Lucio Cascini Umberto Sabatini |
spellingShingle |
Vincenzo Gangemi Chiara Mignogna Giusy Guzzi Angelo Lavano Salvatore Bongarzone Giuseppe Lucio Cascini Umberto Sabatini Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report BMC Cancer |
author_facet |
Vincenzo Gangemi Chiara Mignogna Giusy Guzzi Angelo Lavano Salvatore Bongarzone Giuseppe Lucio Cascini Umberto Sabatini |
author_sort |
Vincenzo Gangemi |
title |
Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report |
title_short |
Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report |
title_full |
Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report |
title_fullStr |
Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report |
title_full_unstemmed |
Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report |
title_sort |
impact of [64cu][cu(atsm)] pet/ct in the evaluation of hypoxia in a patient with glioblastoma: a case report |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2019-12-01 |
description |
Abstract Background Glioblastoma multiform (GBM), a malignant brain tumour, has a very often poor prognosis. The therapeutic approach is represented by surgery followed by radiotherapy and chemotherapy. Hypoxia is a factor that causes a reduction of both radiotherapy and chemotherapy effectiveness in GBM and other cancers. Through the use of [64Cu][Cu(ATSM)], a hypoxia-targeting positron emission tomography (PET) radiotracer, is possible to identify the presence of hypoxic areas within a lesion and therefore modulate the therapeutic approach according to the findings. Case presentation In this case report, we observed an increase of radiotracer uptake from early acquisition to late acquisition in hypoxia sites and high correlation between [64Cu][Cu(ATSM) PET/CT results and expression of the hypoxia marker HIF-1α. Conclusions [64Cu][Cu(ATSM) PET/CT represents a valid opportunity to reveal in vivo hypoxic areas in GBM lesion which can guide clinicians on selecting GMB patient’s therapeutic scheme. |
url |
https://doi.org/10.1186/s12885-019-6368-8 |
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