Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities.
Erythropoietin (Epo)-induced Stat5 phosphorylation (p-Stat5) is essential for both basal erythropoiesis and for its acceleration during hypoxic stress. A key challenge lies in understanding how Stat5 signaling elicits distinct functions during basal and stress erythropoiesis. Here we asked whether t...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-08-01
|
| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC3433736?pdf=render |