A mutation that blocks integrin α4β7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis

A mutation that blocks integrin α4β7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis

Abstract Background β7 integrins are responsible for the efficient recruitment of lymphocytes from the blood and their retention in gut-associated lymphoid tissues. Integrin α4β7 binds MAdCAM-1, mediating rolling adhesion of lymphocytes on blood vessel walls when inactive and firm adhesion when acti...

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Bibliographic Details
Main Authors: Hailong Zhang, Yajuan Zheng, Youdong Pan, Changdong Lin, Shihui Wang, Zhanjun Yan, Ling Lu, Gaoxiang Ge, Jinsong Li, Yi Arial Zeng, Jianfeng Chen
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Biology
Subjects:
Inflammatory bowel disease
Integrin α4β7
Activation
Lymphocyte
Online Access:http://link.springer.com/article/10.1186/s12915-020-00784-6

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http://link.springer.com/article/10.1186/s12915-020-00784-6

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