The modulation of stem cell behaviors by functionalized nanoceramic coatings on Ti-based implants

• Main Authors: Xiangmei Liu, Man Li, Yizhou Zhu, K.W.K. Yeung, Paul K. Chu, Shuilin Wu
• Format: Article
• Language: English
• Published: KeAi Communications Co., Ltd. 2016-09-01
• Series: Bioactive Materials
• Subjects: Nanoceramic coating; Ti; Stem cell; Modulation; Implants
• Online Access: http://www.sciencedirect.com/science/article/pii/S2452199X16300251

Nanoceramic coating on the surface of Ti-based metallic implants is a clinical potential option in orthopedic surgery. Stem cells have been found to have osteogenic capabilities. It is necessary to study the influences of functionalized nanoceramic coatings on the differentiation and proliferation of stem cells in vitro or in vivo. In this paper, we summarized the recent advance on the modulation of stem cells behaviors through controlling the properties of nanoceramic coatings, including surface chemistry, surface roughness and microporosity. In addition, mechanotransduction pathways have also been discussed to reveal the interaction mechanisms between the stem cells and ceramic coatings on Ti-based metals. In the final part, the osteoinduction and osteoconduction of ceramic coating have been also presented when it was used as carrier of BMPs in new bone formation.