Evolutionary Origin of the P2X7 C-ter Region: Capture of an Ancient Ballast Domain by a P2X4-Like Gene in Ancient Jawed Vertebrates

Evolutionary Origin of the P2X7 C-ter Region: Capture of an Ancient Ballast Domain by a P2X4-Like Gene in Ancient Jawed Vertebrates

P2X purinergic receptors are extracellular ATP-gated ion channel receptors present on the cell plasma membrane. P2X receptors have been found in Metazoa, fungi, amoebas, and in plants. In mammals, P2X7 is expressed by a large number of cell types and is involved in inflammation and immunity. Remarka...

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Bibliographic Details
Main Authors: Airi Rump, Olli Pekka Smolander, Sirje Rüütel Boudinot, Jean M. Kanellopoulos, Pierre Boudinot
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
purinercic receptors
P2X7
evolution
ballast domain
NANOR-like proteins
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00113/full

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