An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning

An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning

Loading of mRNA onto the ribosomal 43S pre-initiation complex (PIC) and its subsequent scanning require the removal of the secondary structure of the by RNA helicases such as eIF4A. However, the topology and mechanics of the scanning complex bound to mRNA (48S-PIC) and the influence of its solvent-s...

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Bibliographic Details
Main Authors: Irene Díaz-López, René Toribio, Juan José Berlanga, Iván Ventoso
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
ES6S region
translation
scanning
mRNA secondary structure
G quadruplex
Online Access:https://elifesciences.org/articles/48246

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