Landscape and selection of vaccine epitopes in SARS-CoV-2

Landscape and selection of vaccine epitopes in SARS-CoV-2

Abstract Background Early in the pandemic, we designed a SARS-CoV-2 peptide vaccine containing epitope regions optimized for concurrent B cell, CD4+ T cell, and CD8+ T cell stimulation. The rationale for this design was to drive both humoral and cellular immunity with high specificity while avoiding...

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Bibliographic Details
Main Authors: Christof C. Smith, Kelly S. Olsen, Kaylee M. Gentry, Maria Sambade, Wolfgang Beck, Jason Garness, Sarah Entwistle, Caryn Willis, Steven Vensko, Allison Woods, Misha Fini, Brandon Carpenter, Eric Routh, Julia Kodysh, Timothy O’Donnell, Carsten Haber, Kirsten Heiss, Volker Stadler, Erik Garrison, Adam M. Sandor, Jenny P. Y. Ting, Jared Weiss, Krzysztof Krajewski, Oliver C. Grant, Robert J. Woods, Mark Heise, Benjamin G. Vincent, Alex Rubinsteyn
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Genome Medicine
Subjects:
SARS-CoV-2
COVID-19
vaccine
T cell
B cell
Online Access:https://doi.org/10.1186/s13073-021-00910-1

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