A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time

A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time

An important aspect of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) proposal is the use of human stem cell-derived cardiomyocytes and the confirmation of their predictive power in drug safety assays. The benefits of this cell source are clear; drugs can be tested in vitro on human cardiomyo...

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Bibliographic Details
Main Authors: Birgit Goversen, Nadine Becker, Sonja Stoelzle-Feix, Alison Obergrussberger, Marc A. Vos, Toon A. B. van Veen, Niels Fertig, Teun P. de Boer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Physiology
Subjects:
automated patch clamp electrophysiology
cardiomyocyte
stem cell
dynamic clamp
inward rectifying potassium ion channels
safety pharmacology
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.01094/full

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http://journal.frontiersin.org/article/10.3389/fphys.2017.01094/full

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