Spatial and Temporal Resolution of Global Protein Synthesis during HSV Infection Using Bioorthogonal Precursors and Click Chemistry.

We used pulse-labeling with the methionine analogue homopropargylglycine (HPG) to investigate spatiotemporal aspects of protein synthesis during herpes simplex virus (HSV) infection. In vivo incorporation of HPG enables subsequent selective coupling of fluorochrome-capture reagents to newly synthesi...

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Bibliographic Details
Main Authors: Catherine Su Hui Teo, Remigiusz A Serwa, Peter O'Hare
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5051704?pdf=render

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