Chromosome drives via CRISPR-Cas9 in yeast

Chromosome drives via CRISPR-Cas9 in yeast

Self-propagating drives allow for non-Mendelian inheritance. Here the authors use CRISPR to build a chromosome drive, showing elimination of entire chromosomes, endoreduplication of desired chromosomes and enabling preferential transmissions of complex genetic traits on a chromosomal scale in yeast.

Bibliographic Details
Main Authors: Hui Xu, Mingzhe Han, Shiyi Zhou, Bing-Zhi Li, Yi Wu, Ying-Jin Yuan
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18222-0

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