Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant

Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant

We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricula...

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Main Authors: Lisheng Lin, Miho Takahashi-Igari, Yoshiaki Kato, Yoshihiro Nozaki, Mana Obata, Hiromi Hamada, Hitoshi Horigome
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Case Reports in Pediatrics
Online Access:http://dx.doi.org/10.1155/2017/6570465
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spelling doaj-1bce3903329141ae926551d54af457232020-11-24T23:25:24ZengHindawi LimitedCase Reports in Pediatrics2090-68032090-68112017-01-01201710.1155/2017/65704656570465Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q VariantLisheng Lin0Miho Takahashi-Igari1Yoshiaki Kato2Yoshihiro Nozaki3Mana Obata4Hiromi Hamada5Hitoshi Horigome6Department of Child Health, University of Tsukuba, Tsukuba, JapanDepartment of Child Health, University of Tsukuba, Tsukuba, JapanDepartment of Child Health, University of Tsukuba, Tsukuba, JapanDepartment of Child Health, University of Tsukuba, Tsukuba, JapanDepartment of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, JapanDepartment of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, JapanDepartment of Child Health, University of Tsukuba, Tsukuba, JapanWe report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricular arrhythmias were confirmed after birth. Genetic testing of the baby revealed a SCN5A R1193Q variant, which we considered could account for the various arrhythmias in this case.http://dx.doi.org/10.1155/2017/6570465
collection DOAJ
language English
format Article
sources DOAJ
author Lisheng Lin
Miho Takahashi-Igari
Yoshiaki Kato
Yoshihiro Nozaki
Mana Obata
Hiromi Hamada
Hitoshi Horigome
spellingShingle Lisheng Lin
Miho Takahashi-Igari
Yoshiaki Kato
Yoshihiro Nozaki
Mana Obata
Hiromi Hamada
Hitoshi Horigome
Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
Case Reports in Pediatrics
author_facet Lisheng Lin
Miho Takahashi-Igari
Yoshiaki Kato
Yoshihiro Nozaki
Mana Obata
Hiromi Hamada
Hitoshi Horigome
author_sort Lisheng Lin
title Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
title_short Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
title_full Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
title_fullStr Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
title_full_unstemmed Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant
title_sort prenatal diagnosis of atrioventricular block and qt interval prolongation by fetal magnetocardiography in a fetus with trisomy 18 and scn5a r1193q variant
publisher Hindawi Limited
series Case Reports in Pediatrics
issn 2090-6803
2090-6811
publishDate 2017-01-01
description We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricular arrhythmias were confirmed after birth. Genetic testing of the baby revealed a SCN5A R1193Q variant, which we considered could account for the various arrhythmias in this case.
url http://dx.doi.org/10.1155/2017/6570465
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