LGR5-Positive Supporting Cells Survive Ototoxic Trauma in the Adult Mouse Cochlea

LGR5-Positive Supporting Cells Survive Ototoxic Trauma in the Adult Mouse Cochlea

Sensorineural hearing loss is mainly caused by irreversible damage to sensory hair cells (HCs). A subgroup of supporting cells (SCs) in the cochlea express leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), a marker for tissue-resident stem cells. LGR5+ SCs could be used as an endog...

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Bibliographic Details
Main Authors: Natalia Smith-Cortinez, Rana Yadak, Ferry G. J. Hendriksen, Eefje Sanders, Dyan Ramekers, Robert J. Stokroos, Huib Versnel, Louise V. Straatman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
inner ear regeneration
deafness
LGR5+ supporting cells
ototoxicity
adult mammalian cochlea
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.729625/full

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