A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab

A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab

Ipilimumab is a monoclonal antibody that works as an immunotherapeutic agent through selective targeting of T cells to strengthen the response to metastatic melanoma. It is well known that this pharmaceutical agent can cause the adverse effect of colitis. We report a rare presentation of ileocolitis...

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Main Authors: Behdod Poushanchi, Hiren Vallabh, Gorman Joel Reynolds
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Case Reports in Gastrointestinal Medicine
Online Access:http://dx.doi.org/10.1155/2018/2431503
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spelling doaj-1baa61e105a049e1870c66447b3ed8d62020-11-24T23:46:31ZengHindawi LimitedCase Reports in Gastrointestinal Medicine2090-65282090-65362018-01-01201810.1155/2018/24315032431503A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and InfliximabBehdod Poushanchi0Hiren Vallabh1Gorman Joel Reynolds2Department of Medicine, West Virginia University, Morgantown, WV, USADivision of Gastroenterology, West Virginia University, Morgantown, WV, USADivision of Gastroenterology, West Virginia University, Morgantown, WV, USAIpilimumab is a monoclonal antibody that works as an immunotherapeutic agent through selective targeting of T cells to strengthen the response to metastatic melanoma. It is well known that this pharmaceutical agent can cause the adverse effect of colitis. We report a rare presentation of ileocolitis refractory to both glucocorticosteroids and infliximab with a resultant pneumatosis and perforation requiring subtotal colectomy and end ileostomy.http://dx.doi.org/10.1155/2018/2431503
collection DOAJ
language English
format Article
sources DOAJ
author Behdod Poushanchi
Hiren Vallabh
Gorman Joel Reynolds
spellingShingle Behdod Poushanchi
Hiren Vallabh
Gorman Joel Reynolds
A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
Case Reports in Gastrointestinal Medicine
author_facet Behdod Poushanchi
Hiren Vallabh
Gorman Joel Reynolds
author_sort Behdod Poushanchi
title A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
title_short A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
title_full A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
title_fullStr A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
title_full_unstemmed A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
title_sort severe case of ipilimumab-induced ileocolitis refractory to glucocorticosteroids and infliximab
publisher Hindawi Limited
series Case Reports in Gastrointestinal Medicine
issn 2090-6528
2090-6536
publishDate 2018-01-01
description Ipilimumab is a monoclonal antibody that works as an immunotherapeutic agent through selective targeting of T cells to strengthen the response to metastatic melanoma. It is well known that this pharmaceutical agent can cause the adverse effect of colitis. We report a rare presentation of ileocolitis refractory to both glucocorticosteroids and infliximab with a resultant pneumatosis and perforation requiring subtotal colectomy and end ileostomy.
url http://dx.doi.org/10.1155/2018/2431503
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