A claudin-9-based ion permeability barrier is essential for hearing.

Hereditary hearing loss is one of the most common birth defects, yet the majority of genes required for audition is thought to remain unidentified. Ethylnitrosourea (ENU)-mutagenesis has been a valuable approach for generating new animal models of deafness and discovering previously unrecognized gen...

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Bibliographic Details
Main Authors: Yoko Nakano, Sung H Kim, Hyoung-Mi Kim, Joel D Sanneman, Yuzhou Zhang, Richard J H Smith, Daniel C Marcus, Philine Wangemann, Randy A Nessler, Botond Bánfi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2720454?pdf=render