KCTD1 suppresses canonical Wnt signaling pathway by enhancing β-catenin degradation.

KCTD1 suppresses canonical Wnt signaling pathway by enhancing β-catenin degradation.

The canonical Wnt signaling pathway controls normal embryonic development, cellular proliferation and growth, and its aberrant activity results in human carcinogenesis. The core component in regulation of this pathway is β-catenin, but molecular regulation mechanisms of β-catenin stability are not c...

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Bibliographic Details
Main Authors: Xinxin Li, Cheng Chen, Fangmei Wang, Wenhuan Huang, Zhongheng Liang, Yuzhong Xiao, Ke Wei, Zhenxing Wan, Xiang Hu, Shuanglin Xiang, Xiaofeng Ding, Jian Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3988066?pdf=render

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