Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up

• Main Authors: Tom Shmuly, Yehonatan Ben Zvi, Gabriel Chaushu, Ilana Kaplan
• Format: Article
• Language: English
• Published: MDPI AG 2021-02-01
• Series: Medicina
• Subjects: solitary fibrous tumor; hemangiopericytoma; oral cavity; CD34; immunohistochemistry
• Online Access: https://www.mdpi.com/1010-660X/57/2/152

<i>Background and Objectives:</i> This was a retrospective single-center study to analyze and describe the clinical and histological features of all cases of oral solitary fibrous tumor (SFT). Study design: the study included all consecutive cases of oral SFT diagnosed between 2008–2018 at a single tertiary center. <i>Materials and Methods:</i> Clinical data was retrieved from medical charts. The diagnosis of oral SFT was based upon the morphologic features of the lesions, in routine hematoxylin and eosin (H&E) stained sections and confirmed by immunohistochemical analyses including CD34, CD99, Bcl2, and stains for STAT6. <i>Results:</i> Seven cases of oral SFT were found. Of these, three (42%) were in males and four (58%) in females. The age range was 24–63 years (mean 47 ± 13). Four (58%) lesions were located in the buccal mucosa, two (28%) in the labial mucosa and one (14%) on the floor of the mouth. The diameter ranged between 3–50 mm (mean 22 ± 14 mm). All patients were treated with local excision. Follow-up periods were between 2–74 months (mean 41 ± 27). No recurrences were reported. <i>Conclusions:</i> We present a series of oral SFT, which were all non-aggressive in presentation and did not recur after conservative surgery (local excision) over a relatively long follow-up period.