Daratumumab and Nanobody-Based Heavy Chain Antibodies Inhibit the ADPR Cyclase but not the NAD<sup>+</sup> Hydrolase Activity of CD38-Expressing Multiple Myeloma Cells

Daratumumab and Nanobody-Based Heavy Chain Antibodies Inhibit the ADPR Cyclase but not the NAD<sup>+</sup> Hydrolase Activity of CD38-Expressing Multiple Myeloma Cells

The nucleotides ATP and NAD<sup>+</sup> are released from stressed cells as endogenous danger signals. Ecto-enzymes in the tumor microenvironment hydrolyze these inflammatory nucleotides to immunosuppressive adenosine, thereby, hampering anti-tumor immune responses. The NAD<sup>+&l...

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Bibliographic Details
Main Authors: Natalie Baum, Ralf Fliegert, Andreas Bauche, Julia Hambach, Stephan Menzel, Friedrich Haag, Peter Bannas, Friedrich Koch-Nolte
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
multiple myeloma
CD38
ecto-enzyme
NAD<sup>+</sup> hydrolase
antibodies
heavy-chain antibodies
Online Access:https://www.mdpi.com/2072-6694/13/1/76

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