α-Cyperone Confers Antidepressant-Like Effects in Mice via Neuroplasticity Enhancement by SIRT3/ROS Mediated NLRP3 Inflammasome Deactivation

α-Cyperone Confers Antidepressant-Like Effects in Mice via Neuroplasticity Enhancement by SIRT3/ROS Mediated NLRP3 Inflammasome Deactivation

α-Cyperone (Cy) is a major active compound of Cyperus rotundus that has various pharmacological activities. But whether Cy possesses antidepressant effect is unknown. In this study, we exposed mice to chronic unpredictable mild stress (CUMS) with or without intervention with Cy. Our results showed t...

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Bibliographic Details
Main Authors: Baomei Xia, Yue Tong, Changbo Xia, Chang Chen, Xin Shan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
depression
SIRT3
ROS
NLRP3 inflammasome
neuroplasticity
α-cyperone
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.577062/full

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