miR-377-3p-Mediated EGR1 Downregulation Promotes B[a]P-Induced Lung Tumorigenesis by Wnt/Beta-Catenin Transduction

miR-377-3p-Mediated EGR1 Downregulation Promotes B[a]P-Induced Lung Tumorigenesis by Wnt/Beta-Catenin Transduction

Polycyclic aromatic hydrocarbons (PAHs), particularly benzo[a]pyrene (B[a]P), found in cigarette smoke and air pollution, is an important carcinogen. Nevertheless, early molecular events and related regulatory effects of B[a]P-mediated cell transformation and tumor initiation remain unclear. This st...

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Bibliographic Details
Main Authors: Xinxin Ke, Lulu He, Runan Wang, Jing Shen, Zhengyang Wang, Yifei Shen, Longjiang Fan, Jimin Shao, Hongyan Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
early growth response protein 1
miR-377-3p
malignant transformation
lung tumorigenesis
Wnt/β-catenin pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.699004/full

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