Anti-inflammatory and Anti-ulcer Activities of New Fused Thiazole Derivatives Derived from 2-(2-Oxo-2H-chromen-3-yl)thiazol-4(5H)-one

Anti-inflammatory and Anti-ulcer Activities of New Fused Thiazole Derivatives Derived from 2-(2-Oxo-2H-chromen-3-yl)thiazol-4(5H)-one

The reaction of the 2-(4-oxo-4,5-dihydrothiazol-2-yl)acetonitrile (1) with salicylaldehyde (2) in 1,4-dioxane containing a catalytic amount of piperidine gave the coumarin derivative 3. The latter reacted with different reagents to give pyrano[4,5-b]thiazole, pyrido[4,5-b]thiazole and thieno[5,4-b]t...

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Main Authors: Rafat Mohareb, Fatima Al-Omran, Mahmoud Abdelaziz, Rehab Ibrahim
Format: Article
Language:English
Published: Slovenian Chemical Society 2017-06-01
Series:Acta Chimica Slovenica
Subjects:
4,5-dihydrothiazol
coumarin
pyrimidine
anti inflammatory
antiulcer activity
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/3200
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spelling doaj-1b6a87c4f69e47d58b1ad47fe2d8cc1a2020-11-25T02:32:07ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552017-06-0164234936410.17344/acsi.2017.3200477Anti-inflammatory and Anti-ulcer Activities of New Fused Thiazole Derivatives Derived from 2-(2-Oxo-2H-chromen-3-yl)thiazol-4(5H)-oneRafat Mohareb0Fatima Al-Omran1Mahmoud Abdelaziz2Rehab IbrahimChemistry Department, faculty of science, Cairo universityDepartment of Chemistry, Faculty of Science, Kuwait University, P.O. box 12613, safat 13060, KuwaitChemistry Department, Faculty of Science, Tabuk university, Tabuk 71491, P. O. Box 741, Kingdom of Saudi ArabiaThe reaction of the 2-(4-oxo-4,5-dihydrothiazol-2-yl)acetonitrile (1) with salicylaldehyde (2) in 1,4-dioxane containing a catalytic amount of piperidine gave the coumarin derivative 3. The latter reacted with different reagents to give pyrano[4,5-b]thiazole, pyrido[4,5-b]thiazole and thieno[5,4-b]thiazole dereivatives. The anti-inflammatory and anti-ulcer activities of the newly synthesized products were evaluated and the results showed that compounds 7a, 8a, 10b, 13b, 15b, 18a, 19b, 19c, and 19d showed higher activity compared to the rest of the compounds. In addition to this, toxicity of such active compounds was studied against shrimp larvae where compounds 10b, 18a, 19c and 19d showed to be non-toxic against the tested organisms.https://journals.matheo.si/index.php/ACSi/article/view/32004,5-dihydrothiazolcoumarinpyrimidineanti inflammatoryantiulcer activity
collection DOAJ
language English
format Article
sources DOAJ
author Rafat Mohareb
Fatima Al-Omran
Mahmoud Abdelaziz
Rehab Ibrahim
spellingShingle Rafat Mohareb
Fatima Al-Omran
Mahmoud Abdelaziz
Rehab Ibrahim
Anti-inflammatory and Anti-ulcer Activities of New Fused Thiazole Derivatives Derived from 2-(2-Oxo-2H-chromen-3-yl)thiazol-4(5H)-one
Acta Chimica Slovenica
4,5-dihydrothiazol
coumarin
pyrimidine
anti inflammatory
antiulcer activity
author_facet Rafat Mohareb
Fatima Al-Omran
Mahmoud Abdelaziz
Rehab Ibrahim
author_sort Rafat Mohareb
title Anti-inflammatory and Anti-ulcer Activities of New Fused Thiazole Derivatives Derived from 2-(2-Oxo-2H-chromen-3-yl)thiazol-4(5H)-one
title_short Anti-inflammatory and Anti-ulcer Activities of New Fused Thiazole Derivatives Derived from 2-(2-Oxo-2H-chromen-3-yl)thiazol-4(5H)-one
title_full Anti-inflammatory and Anti-ulcer Activities of New Fused Thiazole Derivatives Derived from 2-(2-Oxo-2H-chromen-3-yl)thiazol-4(5H)-one
title_fullStr Anti-inflammatory and Anti-ulcer Activities of New Fused Thiazole Derivatives Derived from 2-(2-Oxo-2H-chromen-3-yl)thiazol-4(5H)-one
title_full_unstemmed Anti-inflammatory and Anti-ulcer Activities of New Fused Thiazole Derivatives Derived from 2-(2-Oxo-2H-chromen-3-yl)thiazol-4(5H)-one
title_sort anti-inflammatory and anti-ulcer activities of new fused thiazole derivatives derived from 2-(2-oxo-2h-chromen-3-yl)thiazol-4(5h)-one
publisher Slovenian Chemical Society
series Acta Chimica Slovenica
issn 1318-0207
1580-3155
publishDate 2017-06-01
description The reaction of the 2-(4-oxo-4,5-dihydrothiazol-2-yl)acetonitrile (1) with salicylaldehyde (2) in 1,4-dioxane containing a catalytic amount of piperidine gave the coumarin derivative 3. The latter reacted with different reagents to give pyrano[4,5-b]thiazole, pyrido[4,5-b]thiazole and thieno[5,4-b]thiazole dereivatives. The anti-inflammatory and anti-ulcer activities of the newly synthesized products were evaluated and the results showed that compounds 7a, 8a, 10b, 13b, 15b, 18a, 19b, 19c, and 19d showed higher activity compared to the rest of the compounds. In addition to this, toxicity of such active compounds was studied against shrimp larvae where compounds 10b, 18a, 19c and 19d showed to be non-toxic against the tested organisms.
topic 4,5-dihydrothiazol
coumarin
pyrimidine
anti inflammatory
antiulcer activity
url https://journals.matheo.si/index.php/ACSi/article/view/3200
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AT fatimaalomran antiinflammatoryandantiulceractivitiesofnewfusedthiazolederivativesderivedfrom22oxo2hchromen3ylthiazol45hone
AT mahmoudabdelaziz antiinflammatoryandantiulceractivitiesofnewfusedthiazolederivativesderivedfrom22oxo2hchromen3ylthiazol45hone
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