Preparation, biodistribution and neurotoxicity of liposomal cisplatin following convection enhanced delivery in normal and F98 glioma bearing rats.

The purpose of this study was to evaluate two novel liposomal formulations of cisplatin as potential therapeutic agents for treatment of the F98 rat glioma. The first was a commercially produced agent, Lipoplatin™, which currently is in a Phase III clinical trial for treatment of non-small cell lung...

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Main Authors: Tianyao Huo, Rolf F Barth, Weilian Yang, Robin J Nakkula, Rumiana Koynova, Boris Tenchov, Abhik Ray Chaudhury, Lawrence Agius, Teni Boulikas, Helene Elleaume, Robert J Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3496719?pdf=render