A Nanoparticle Based Sp17 Peptide Vaccine Exposes New Immuno-Dominant and Species Cross-reactive B Cell Epitopes

A Nanoparticle Based Sp17 Peptide Vaccine Exposes New Immuno-Dominant and Species Cross-reactive B Cell Epitopes

Sperm protein antigen 17 (Sp17), expressed in primary as well as in metastatic lesions in >83% of patients with ovarian cancer, is a promising ovarian cancer vaccine candidate. Herein we describe the formulation of nanoparticle based vaccines based on human Sp17 (hSp17) sequence derived pepti...

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Bibliographic Details
Main Authors: Sue D. Xiang, Qian Gao, Kirsty L. Wilson, Arne Heyerick, Magdalena Plebanski
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Vaccines
Subjects:
nanoparticles
ovarian
cancer
vaccine
testis-antigen
antibody
cross-reactivity
immunodomunant
Sp17
Online Access:http://www.mdpi.com/2076-393X/3/4/875

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