Mechanisms of Graft-versus-Host Disease Prevention by Post-transplantation Cyclophosphamide: An Evolving Understanding

Mechanisms of Graft-versus-Host Disease Prevention by Post-transplantation Cyclophosphamide: An Evolving Understanding

Post-transplantation cyclophosphamide (PTCy) has been highly successful at preventing severe acute and chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). The clinical application of this approach was based on extensive studies in major histocompatibil...

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Bibliographic Details
Main Authors: Natalia S. Nunes, Christopher G. Kanakry
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
post-transplantation cyclophosphamide
haploidentical allogeneic hematopoietic cell transplantation
graft-versus-host disease
skin allograft rejection
alloreactive T cells
tolerance
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02668/full

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