Mouse zygotes respond to severe sperm DNA damage by delaying paternal DNA replication and embryonic development.

Mouse zygotes respond to severe sperm DNA damage by delaying paternal DNA replication and embryonic development.

Mouse zygotes do not activate apoptosis in response to DNA damage. We previously reported a unique form of inducible sperm DNA damage termed sperm chromatin fragmentation (SCF). SCF mirrors some aspects of somatic cell apoptosis in that the DNA degradation is mediated by reversible double strand bre...

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Bibliographic Details
Main Authors: Joanna E Gawecka, Joel Marh, Michael Ortega, Yasuhiro Yamauchi, Monika A Ward, W Steven Ward
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3576397?pdf=render

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