Possible Role of Amyloidogenic Evolvability in Dementia with Lewy Bodies: Insights from Transgenic Mice Expressing P123H β-Synuclein

Possible Role of Amyloidogenic Evolvability in Dementia with Lewy Bodies: Insights from Transgenic Mice Expressing P123H β-Synuclein

Dementia with Lewy bodies (DLB) is the second most prevalent neurodegenerative dementia after Alzheimer’s disease, and is pathologically characterized by formation of intracellular inclusions called Lewy bodies, the major constituent of which is aggregated α-synuclein (αS). Currently, neither a mech...

Full description

Bibliographic Details
Main Authors:	Masayo Fujita, Gilbert Ho, Yoshiki Takamatsu, Ryoko Wada, Kazutaka Ikeda, Makoto Hashimoto
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Series:	International Journal of Molecular Sciences
Subjects:	Dementia with Lewy bodies (DLB) α-synuclein (αS) β-synuclein (βS) P123H βS transgenic (Tg) mice amyloidogenic evolvability
Online Access:	https://www.mdpi.com/1422-0067/21/8/2849

Similar Items

Possible Alterations in β-Synuclein, the Non-Amyloidogenic Homologue of α-Synuclein, during Progression of Sporadic α-Synucleinopathies
by: Makoto Hashimoto, et al.
Published: (2012-09-01)

Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein
by: Sekigawa Akio, et al.
Published: (2012-09-01)

Therapeutic Potential of αS Evolvability for NeuropathicGaucher Disease
by: Jianshe Wei, et al.
Published: (2021-02-01)

Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations
by: Bartels, T., et al.
Published: (2022)

Role of α- and β-Synucleins in the Axonal Pathology of Parkinson’s Disease and Related Synucleinopathies
by: Akio Sekigawa, et al.
Published: (2015-05-01)

α-Synuclein Aggregated with Tau and β-Amyloid in Human Platelets from Healthy Subjects: Correlation with Physical Exercise
by: Simona Daniele, et al.
Published: (2018-01-01)

Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro
by: Janett Köppen, et al.
Published: (2020-01-01)

Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy
by: Yuta Takaichi, et al.
Published: (2020-06-01)

α-Synuclein Heterocomplexes with β-Amyloid Are Increased in Red Blood Cells of Parkinson’s Disease Patients and Correlate with Disease Severity
by: Simona Daniele, et al.
Published: (2018-02-01)

Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
by: Grace M. Lloyd, et al.
Published: (2021-09-01)

Effect of superparamagnetic nanoparticles coated with various electric charges on α-synuclein and β-amyloid proteins fibrillation process
by: Javdani N, et al.
Published: (2019-01-01)

Development of α-Synuclein Real-Time Quaking-Induced Conversion as a Diagnostic Method for α-Synucleinopathies
by: Takehiro Nakagaki, et al.
Published: (2021-09-01)

Alternative Splicing of Alpha- and Beta-Synuclein Genes Plays Differential Roles in Synucleinopathies
by: Ana Gámez-Valero, et al.
Published: (2018-01-01)

Alpha-Synuclein Pathology Coincides With Increased Number of Early Stage Neural Progenitors in the Adult Hippocampus
by: Hannah Bender, et al.
Published: (2021-07-01)

α-synuclein in the pathophysiology of Alzheimer’s disease
by: Daniel Twohig, et al.
Published: (2019-06-01)

Immature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant β-synuclein
by: Hideo Hagihara, et al.
Published: (2018-07-01)

Multi-Loop Model of Alzheimer Disease: An Integrated Perspective on the Wnt/GSK3β, α-Synuclein, and Type 3 Diabetes Hypotheses
by: Nicholas G. Norwitz, et al.
Published: (2019-07-01)

Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein
by: Andre Leitao, et al.
Published: (2018-01-01)

Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates
by: Jinar Rostami, et al.
Published: (2021-06-01)

Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers
by: Tomohiro Umeda, et al.
Published: (2021-08-01)

Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity
by: Oeystein R. Brekk, et al.
Published: (2020-08-01)

Serum α-synuclein and IL-1β are increased and correlated with measures of disease severity in children with epilepsy: potential prognostic biomarkers?
by: Jieun Choi, et al.
Published: (2020-03-01)

Patient-Derived Induced Pluripotent Stem Cells and Organoids for Modeling Alpha Synuclein Propagation in Parkinson's Disease
by: Yong Hui Koh, et al.
Published: (2018-11-01)

Amyloid-β and α-Synuclein Immunotherapy: From Experimental Studies to Clinical Trials
by: Jacqui Taryn Nimmo, et al.
Published: (2021-09-01)

Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression
by: Zachary A. Sorrentino, et al.
Published: (2019-09-01)

α-Synuclein and DJ-1 as Potential Biological Fluid Biomarkers for Parkinson’s Disease
by: Makoto Hashimoto, et al.
Published: (2010-10-01)

On α-synuclein in the Human Enteric Nervous System
by: Gray, Madison T.
Published: (2014)

On α-synuclein in the Human Enteric Nervous System
by: Gray, Madison T.
Published: (2014)

Melatonin and other tryptophan metabolites produced by yeasts: implications in cardiovascular and neurodegenerative diseases
by: Ruth eHornedo-Ortega, et al.
Published: (2016-01-01)

Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models
by: Michiyo Iba, et al.
Published: (2020-07-01)

Native α-Synuclein, 3-Nitrotyrosine Proteins, and Patterns of Nitro-α-Synuclein-Immunoreactive Inclusions in Saliva and Submandibulary Gland in Parkinson’s Disease
by: Emilio Fernández-Espejo, et al.
Published: (2021-05-01)

Initiation and propagation of α-synuclein aggregation in the nervous system
by: Baraa A. Hijaz, et al.
Published: (2020-03-01)

Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s disease
by: Zheng Fan, et al.
Published: (2020-01-01)

Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy
by: Martin Kallab, et al.
Published: (2018-07-01)

α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons
by: Jessica M. Froula, et al.
Published: (2018-05-01)

Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein
by: Xiang Zhang, et al.
Published: (2014-03-01)

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration
by: Xinhe Wang, et al.
Published: (2019-03-01)

The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson’s Disease
by: Kai-Jung Lin, et al.
Published: (2019-10-01)

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers
by: Ryan Limbocker, et al.
Published: (2021-06-01)

Neuroprotective function of Omi to α-synuclein-induced neurotoxicity
by: Hea-Jong Chung, et al.
Published: (2020-03-01)