Icaritin Alleviates Glutamate-Induced Neuronal Damage by Inactivating GluN2B-Containing NMDARs Through the ERK/DAPK1 Pathway

Icaritin Alleviates Glutamate-Induced Neuronal Damage by Inactivating GluN2B-Containing NMDARs Through the ERK/DAPK1 Pathway

Excitatory toxicity due to excessive glutamate release is considered the core pathophysiological mechanism of cerebral ischemia. It is primarily mediated by N-methyl-D-aspartate receptors (NMDARs) on neuronal membranes. Our previous studies have found that icaritin (ICT) exhibits neuroprotective eff...

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Bibliographic Details
Main Authors:	Song Liu, Chaoming Liu, Lijiao Xiong, Jiali Xie, Cheng Huang, Rongbiao Pi, Zhihua Huang, Liangdong Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Neuroscience
Subjects:	icaritin NMDA receptor GluN2B GluN2A ERK1/2/DAPK1 pathway
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2021.525615/full

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