ColE1-plasmid production in Escherichia coli: Mathematical Simulation and Experimental Validation

ColE1-plasmid production in Escherichia coli: Mathematical Simulation and Experimental Validation

Plasmids have become very important as pharmaceutical gene vectors in the fields of gene therapy and genetic vaccination in the last years. In this study, we present a dynamic model to simulate the ColE1-like plasmid replication control, once for a DH5α-strain carrying a low copy plasmid (DH5α-pSUP...

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Bibliographic Details
Main Authors: Inga eFreudenau, Petra eLutter, Ruth eBayer, Martin eSchleef, Hanna eBednarz, Alvaro R Lara, Karsten eNiehaus
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Biotechnology
modeling
small RNA
ordinary differential equations
Plasmid replication
uncharged tRNA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00127/full

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