Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis

Abstract Background The present analysis was designed to investigate the association of type 2 diabetes (T2D) with high sensitivity cardiac troponin T (hs-cTnT) during the 5 years of follow-up, and explore which one of fasting blood glucose (FBG) and postprandial blood glucose (PBG) is a determinant...

Full description

Bibliographic Details
Main Authors: Shihui Fu, Rongjie Jin, Leiming Luo, Ping Ye
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Nutrition & Metabolism
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12986-017-0229-8
id doaj-1b37b4c103d844e999f5b1f649f27fb8
record_format Article
spelling doaj-1b37b4c103d844e999f5b1f649f27fb82020-11-24T22:58:48ZengBMCNutrition & Metabolism1743-70752017-11-011411610.1186/s12986-017-0229-8Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysisShihui Fu0Rongjie Jin1Leiming Luo2Ping Ye3Department of Geriatric Cardiology, Chinese People’s Liberation Army General HospitalDepartment of Cardiology and Hainan Branch, Chinese People’s Liberation Army General HospitalDepartment of Geriatric Cardiology, Chinese People’s Liberation Army General HospitalDepartment of Geriatric Cardiology, Chinese People’s Liberation Army General HospitalAbstract Background The present analysis was designed to investigate the association of type 2 diabetes (T2D) with high sensitivity cardiac troponin T (hs-cTnT) during the 5 years of follow-up, and explore which one of fasting blood glucose (FBG) and postprandial blood glucose (PBG) is a determinant of this association in Chinese community-dwelling population. Methods This prospective community-based analysis was conducted based on 730 participants without coronary artery disease and hs-cTnT values ≥14 pg/mL receiving two measurements of hs-cTnT levels at baseline and follow-up of 5 years. Results Prevalence of T2D was 16.2% (118 participants). Median hs-cTnT levels were 4 (3-7) pg/mL and 6 (5-9) pg/mL at baseline and follow-up, respectively. The variation in hs-cTnT levels had a median of 2 (0-4) pg/ml (p < 0.001 for variation), and incidence of hs-cTnT levels ≥14 pg/ml was 7.1% (52 participants) at follow-up. T2D had a significant association with elevated hs-cTnT levels in multivariate Logistic regression models (p < 0.05). Elevated levels of PBG (p < 0.05) rather than FBG (p > 0.05) determined the significant association with elevated hs-cTnT levels in multivariate linear regression models. Conclusions This community-based analysis observed that there was a significant increment of hs-cTnT levels, and baseline T2D had a significant association with elevated hs-cTnT levels during the 5 years of follow-up. Moreover, the present analysis demonstrated that PBG rather than FBG played a crucial role in this association in Chinese community-dwelling population without CAD.http://link.springer.com/article/10.1186/s12986-017-0229-8Chinese community-dwelling populationFasting blood glucoseHigh sensitivity cardiac troponin TPostprandial blood glucoseType 2 diabetes
collection DOAJ
language English
format Article
sources DOAJ
author Shihui Fu
Rongjie Jin
Leiming Luo
Ping Ye
spellingShingle Shihui Fu
Rongjie Jin
Leiming Luo
Ping Ye
Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis
Nutrition & Metabolism
Chinese community-dwelling population
Fasting blood glucose
High sensitivity cardiac troponin T
Postprandial blood glucose
Type 2 diabetes
author_facet Shihui Fu
Rongjie Jin
Leiming Luo
Ping Ye
author_sort Shihui Fu
title Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis
title_short Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis
title_full Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis
title_fullStr Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis
title_full_unstemmed Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis
title_sort baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin t levels in chinese community-dwelling population: a 5-year prospective analysis
publisher BMC
series Nutrition & Metabolism
issn 1743-7075
publishDate 2017-11-01
description Abstract Background The present analysis was designed to investigate the association of type 2 diabetes (T2D) with high sensitivity cardiac troponin T (hs-cTnT) during the 5 years of follow-up, and explore which one of fasting blood glucose (FBG) and postprandial blood glucose (PBG) is a determinant of this association in Chinese community-dwelling population. Methods This prospective community-based analysis was conducted based on 730 participants without coronary artery disease and hs-cTnT values ≥14 pg/mL receiving two measurements of hs-cTnT levels at baseline and follow-up of 5 years. Results Prevalence of T2D was 16.2% (118 participants). Median hs-cTnT levels were 4 (3-7) pg/mL and 6 (5-9) pg/mL at baseline and follow-up, respectively. The variation in hs-cTnT levels had a median of 2 (0-4) pg/ml (p < 0.001 for variation), and incidence of hs-cTnT levels ≥14 pg/ml was 7.1% (52 participants) at follow-up. T2D had a significant association with elevated hs-cTnT levels in multivariate Logistic regression models (p < 0.05). Elevated levels of PBG (p < 0.05) rather than FBG (p > 0.05) determined the significant association with elevated hs-cTnT levels in multivariate linear regression models. Conclusions This community-based analysis observed that there was a significant increment of hs-cTnT levels, and baseline T2D had a significant association with elevated hs-cTnT levels during the 5 years of follow-up. Moreover, the present analysis demonstrated that PBG rather than FBG played a crucial role in this association in Chinese community-dwelling population without CAD.
topic Chinese community-dwelling population
Fasting blood glucose
High sensitivity cardiac troponin T
Postprandial blood glucose
Type 2 diabetes
url http://link.springer.com/article/10.1186/s12986-017-0229-8
work_keys_str_mv AT shihuifu baselinetype2diabeteshadasignificantassociationwithelevatedhighsensitivitycardiactroponintlevelsinchinesecommunitydwellingpopulationa5yearprospectiveanalysis
AT rongjiejin baselinetype2diabeteshadasignificantassociationwithelevatedhighsensitivitycardiactroponintlevelsinchinesecommunitydwellingpopulationa5yearprospectiveanalysis
AT leimingluo baselinetype2diabeteshadasignificantassociationwithelevatedhighsensitivitycardiactroponintlevelsinchinesecommunitydwellingpopulationa5yearprospectiveanalysis
AT pingye baselinetype2diabeteshadasignificantassociationwithelevatedhighsensitivitycardiactroponintlevelsinchinesecommunitydwellingpopulationa5yearprospectiveanalysis
_version_ 1725646481383227392