Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis
Abstract Background The present analysis was designed to investigate the association of type 2 diabetes (T2D) with high sensitivity cardiac troponin T (hs-cTnT) during the 5 years of follow-up, and explore which one of fasting blood glucose (FBG) and postprandial blood glucose (PBG) is a determinant...
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doaj-1b37b4c103d844e999f5b1f649f27fb82020-11-24T22:58:48ZengBMCNutrition & Metabolism1743-70752017-11-011411610.1186/s12986-017-0229-8Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysisShihui Fu0Rongjie Jin1Leiming Luo2Ping Ye3Department of Geriatric Cardiology, Chinese People’s Liberation Army General HospitalDepartment of Cardiology and Hainan Branch, Chinese People’s Liberation Army General HospitalDepartment of Geriatric Cardiology, Chinese People’s Liberation Army General HospitalDepartment of Geriatric Cardiology, Chinese People’s Liberation Army General HospitalAbstract Background The present analysis was designed to investigate the association of type 2 diabetes (T2D) with high sensitivity cardiac troponin T (hs-cTnT) during the 5 years of follow-up, and explore which one of fasting blood glucose (FBG) and postprandial blood glucose (PBG) is a determinant of this association in Chinese community-dwelling population. Methods This prospective community-based analysis was conducted based on 730 participants without coronary artery disease and hs-cTnT values ≥14 pg/mL receiving two measurements of hs-cTnT levels at baseline and follow-up of 5 years. Results Prevalence of T2D was 16.2% (118 participants). Median hs-cTnT levels were 4 (3-7) pg/mL and 6 (5-9) pg/mL at baseline and follow-up, respectively. The variation in hs-cTnT levels had a median of 2 (0-4) pg/ml (p < 0.001 for variation), and incidence of hs-cTnT levels ≥14 pg/ml was 7.1% (52 participants) at follow-up. T2D had a significant association with elevated hs-cTnT levels in multivariate Logistic regression models (p < 0.05). Elevated levels of PBG (p < 0.05) rather than FBG (p > 0.05) determined the significant association with elevated hs-cTnT levels in multivariate linear regression models. Conclusions This community-based analysis observed that there was a significant increment of hs-cTnT levels, and baseline T2D had a significant association with elevated hs-cTnT levels during the 5 years of follow-up. Moreover, the present analysis demonstrated that PBG rather than FBG played a crucial role in this association in Chinese community-dwelling population without CAD.http://link.springer.com/article/10.1186/s12986-017-0229-8Chinese community-dwelling populationFasting blood glucoseHigh sensitivity cardiac troponin TPostprandial blood glucoseType 2 diabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shihui Fu Rongjie Jin Leiming Luo Ping Ye |
spellingShingle |
Shihui Fu Rongjie Jin Leiming Luo Ping Ye Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis Nutrition & Metabolism Chinese community-dwelling population Fasting blood glucose High sensitivity cardiac troponin T Postprandial blood glucose Type 2 diabetes |
author_facet |
Shihui Fu Rongjie Jin Leiming Luo Ping Ye |
author_sort |
Shihui Fu |
title |
Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis |
title_short |
Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis |
title_full |
Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis |
title_fullStr |
Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis |
title_full_unstemmed |
Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis |
title_sort |
baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin t levels in chinese community-dwelling population: a 5-year prospective analysis |
publisher |
BMC |
series |
Nutrition & Metabolism |
issn |
1743-7075 |
publishDate |
2017-11-01 |
description |
Abstract Background The present analysis was designed to investigate the association of type 2 diabetes (T2D) with high sensitivity cardiac troponin T (hs-cTnT) during the 5 years of follow-up, and explore which one of fasting blood glucose (FBG) and postprandial blood glucose (PBG) is a determinant of this association in Chinese community-dwelling population. Methods This prospective community-based analysis was conducted based on 730 participants without coronary artery disease and hs-cTnT values ≥14 pg/mL receiving two measurements of hs-cTnT levels at baseline and follow-up of 5 years. Results Prevalence of T2D was 16.2% (118 participants). Median hs-cTnT levels were 4 (3-7) pg/mL and 6 (5-9) pg/mL at baseline and follow-up, respectively. The variation in hs-cTnT levels had a median of 2 (0-4) pg/ml (p < 0.001 for variation), and incidence of hs-cTnT levels ≥14 pg/ml was 7.1% (52 participants) at follow-up. T2D had a significant association with elevated hs-cTnT levels in multivariate Logistic regression models (p < 0.05). Elevated levels of PBG (p < 0.05) rather than FBG (p > 0.05) determined the significant association with elevated hs-cTnT levels in multivariate linear regression models. Conclusions This community-based analysis observed that there was a significant increment of hs-cTnT levels, and baseline T2D had a significant association with elevated hs-cTnT levels during the 5 years of follow-up. Moreover, the present analysis demonstrated that PBG rather than FBG played a crucial role in this association in Chinese community-dwelling population without CAD. |
topic |
Chinese community-dwelling population Fasting blood glucose High sensitivity cardiac troponin T Postprandial blood glucose Type 2 diabetes |
url |
http://link.springer.com/article/10.1186/s12986-017-0229-8 |
work_keys_str_mv |
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