An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.

An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.

Three new compounds, enhygromic acid (1) and deoxyenhygrolides A (2) and B (3), were isolated from a marine myxobacterium, Enhygromyxa sp. Compound 1 was found to be an acrylic acid derivative with a rare polycyclic carbon skeleton, decahydroacenaphthylene, by spectroscopic analyses. Compounds 2 and...

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Bibliographic Details
Main Authors: Tomohiko Tomura, Shiori Nagashima, Satoshi Yamazaki, Takashi Iizuka, Ryosuke Fudou, Makoto Ojika
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:Marine Drugs
Subjects:
marine myxobacterium
diterpene
NGF-enhancing activity
cytotoxicity
antibacterial activity
Online Access:http://www.mdpi.com/1660-3397/15/4/109
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spelling doaj-1b32e6b1917c4e3ca3f7da861850302c2020-11-24T20:41:23ZengMDPI AGMarine Drugs1660-33972017-04-0115410910.3390/md15040109md15040109An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.Tomohiko Tomura0Shiori Nagashima1Satoshi Yamazaki2Takashi Iizuka3Ryosuke Fudou4Makoto Ojika5Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, JapanGraduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, JapanGraduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, JapanInstitute for Innovation, Ajinomoto Co., Inc., Kawasaki, Kanagawa 210-8681, JapanR & D Planning Department, Ajinomoto Co., Inc., Chuo-ku, Tokyo 104-8315, JapanGraduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, JapanThree new compounds, enhygromic acid (1) and deoxyenhygrolides A (2) and B (3), were isolated from a marine myxobacterium, Enhygromyxa sp. Compound 1 was found to be an acrylic acid derivative with a rare polycyclic carbon skeleton, decahydroacenaphthylene, by spectroscopic analyses. Compounds 2 and 3 were deoxy analogs of the known γ-alkylidenebutenolides, enhygrolides. Compound 1 exhibited cytotoxicity against B16 melanoma cells and anti-bacterial activity against Bacillus subtilis, and enhanced the NGF-induced neurite outgrowth of PC12 cells.http://www.mdpi.com/1660-3397/15/4/109marine myxobacteriumditerpeneNGF-enhancing activitycytotoxicityantibacterial activity
collection DOAJ
language English
format Article
sources DOAJ
author Tomohiko Tomura
Shiori Nagashima
Satoshi Yamazaki
Takashi Iizuka
Ryosuke Fudou
Makoto Ojika
spellingShingle Tomohiko Tomura
Shiori Nagashima
Satoshi Yamazaki
Takashi Iizuka
Ryosuke Fudou
Makoto Ojika
An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
Marine Drugs
marine myxobacterium
diterpene
NGF-enhancing activity
cytotoxicity
antibacterial activity
author_facet Tomohiko Tomura
Shiori Nagashima
Satoshi Yamazaki
Takashi Iizuka
Ryosuke Fudou
Makoto Ojika
author_sort Tomohiko Tomura
title An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
title_short An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
title_full An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
title_fullStr An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
title_full_unstemmed An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
title_sort unusual diterpene—enhygromic acid and deoxyenhygrolides from a marine myxobacterium, enhygromyxa sp.
publisher MDPI AG
series Marine Drugs
issn 1660-3397
publishDate 2017-04-01
description Three new compounds, enhygromic acid (1) and deoxyenhygrolides A (2) and B (3), were isolated from a marine myxobacterium, Enhygromyxa sp. Compound 1 was found to be an acrylic acid derivative with a rare polycyclic carbon skeleton, decahydroacenaphthylene, by spectroscopic analyses. Compounds 2 and 3 were deoxy analogs of the known γ-alkylidenebutenolides, enhygrolides. Compound 1 exhibited cytotoxicity against B16 melanoma cells and anti-bacterial activity against Bacillus subtilis, and enhanced the NGF-induced neurite outgrowth of PC12 cells.
topic marine myxobacterium
diterpene
NGF-enhancing activity
cytotoxicity
antibacterial activity
url http://www.mdpi.com/1660-3397/15/4/109
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