The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling

The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling

Abstract Cardiac septum malformations account for the largest proportion in congenital heart defects. The transcription factor Sox7 has critical functions in the vascular development and angiogenesis. It is unclear whether Sox7 also contributes to cardiac septation development. We identified a de no...

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Bibliographic Details
Main Authors: Nanchao Hong, Erge Zhang, Huilin Xie, Lihui Jin, Qi Zhang, Yanan Lu, Alex F. Chen, Yongguo Yu, Bin Zhou, Sun Chen, Yu Yu, Kun Sun
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03658-z

Internet

https://doi.org/10.1038/s41419-021-03658-z

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