Analysis of thrombelastography in type 2 diabetes patients complicated with angina pectoris of coronary heart disease and its correlation with disease severity

• Main Authors: Hong-Hong Liu, Zhao-Chuan Liu, Hong-Tao Liu, Yu-Ji Zhang, Qing-Ling Fu, Jun-Ling Wang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-01-01
• Series: Journal of Hainan Medical University
• Subjects: Type 2 diabetes; Angina pectoris of coronary heart disease; Thrombelastography; Inflammation
• Online Access: http://www.hnykdxxb.com/PDF/201601/32-35.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To analyze the thrombelastography parameters in type 2 diabetes patients complicated with angina pectoris of coronary heart disease and their correlation with disease severity. Methods: 30 cases of healthy volunteers, 30 cases of patients with simple angina pectoris of coronary heart disease (CHD) and 30 cases of type 2 diabetes patients complicated with angina pectoris of coronary heart disease were selected for study. Thrombelastography parameters R value, K value, α angle and MA value as well as inflammation-associated molecules YKL-40 and NK-kB expression were detected. Results: R values and K values of simple CHD group and diabetes complicated with CHD group were lower than those of control group, and α angle and MA values were higher than those of control group; R values and K values of diabetes complicated with CHD group were lower than those of simple CHD group, and α angle and MA values were higher than those of simple CHD group; R values and K values of 2 branch lesions group and 3 branch lesions group were lower than those of 1 branch lesion group, and α angle and MA values as well as YKL-40 and NK-kB contents were higher than those of 1 branch lesion group; R values and K values of 3 branch lesions group were lower than those of 2 branch lesions group, and α angle and MA values as well as YKL- 40 and NK-kB contents were higher than those of 2 branch lesions group; R value and K value were negatively correlated with YKL-40 and NK-kB contents, and α angle and MA value were positively correlated with YKL-40 and NK-kB contents. Conclusions: Thrombelastography parameters in type 2 diabetes patients complicated with angina pectoris of coronary heart disease are significantly abnormal, and R value, K value, α angle and MA value can reflect disease severity and inflammation degree.