Ácidos ciclopentênicos do óleo da sapucainha (Carpotroche brasiliensis Endl, Flacourtiaceae): o primeiro antileprótico usado no Brasil Cyclopentenyl acids from sapucainha oil (Carpotroche brasiliensis Endl, Flacourtiaceae): the first antileprotic used in Brazil

<abstract language="eng">The chaoolmugra oil is one of the oldest medicines used for leprosy until the development of sulfas. In Brazil, it is known as sapucainha oil that is obtained from Carpotroche brasilienesis seeds (Flacourtiaceae). Chemical and medicinal studies of sapucainha...

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Main Authors: Adriana S. Oliveira, Josélia A. Lima, Claudia M. Rezende, Angelo C. Pinto
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2009-01-01
Series:Química Nova
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000100027
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spelling doaj-1b205dd4b5af4304917ebc02a05b68902020-11-25T01:11:37ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642009-01-0132113914510.1590/S0100-40422009000100027Ácidos ciclopentênicos do óleo da sapucainha (Carpotroche brasiliensis Endl, Flacourtiaceae): o primeiro antileprótico usado no Brasil Cyclopentenyl acids from sapucainha oil (Carpotroche brasiliensis Endl, Flacourtiaceae): the first antileprotic used in BrazilAdriana S. OliveiraJosélia A. LimaClaudia M. RezendeAngelo C. Pinto<abstract language="eng">The chaoolmugra oil is one of the oldest medicines used for leprosy until the development of sulfas. In Brazil, it is known as sapucainha oil that is obtained from Carpotroche brasilienesis seeds (Flacourtiaceae). Chemical and medicinal studies of sapucainha oil were introduced in Brazil by Peckolt, Cole and Cardoso which showed that major ciclopentenyl fatty acids as chaulmoogric, hydnocarpic and gorlic were responsible for its bactericidal activity. In this work, a method for quantification of sapucainha oil acidic fraction by HRGC was established using methyl n-heptadecanoate as internal standard. The oil chemical stability was investigated by the use of GC-MS, IR, ¹H and 13C NMR and showed that the main degradation products belong to the cyclopentenyl moiety oxidation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000100027Carpotroche brasiliensiscyclopentenyl fatty acidsantileprotic
collection DOAJ
language English
format Article
sources DOAJ
author Adriana S. Oliveira
Josélia A. Lima
Claudia M. Rezende
Angelo C. Pinto
spellingShingle Adriana S. Oliveira
Josélia A. Lima
Claudia M. Rezende
Angelo C. Pinto
Ácidos ciclopentênicos do óleo da sapucainha (Carpotroche brasiliensis Endl, Flacourtiaceae): o primeiro antileprótico usado no Brasil Cyclopentenyl acids from sapucainha oil (Carpotroche brasiliensis Endl, Flacourtiaceae): the first antileprotic used in Brazil
Química Nova
Carpotroche brasiliensis
cyclopentenyl fatty acids
antileprotic
author_facet Adriana S. Oliveira
Josélia A. Lima
Claudia M. Rezende
Angelo C. Pinto
author_sort Adriana S. Oliveira
title Ácidos ciclopentênicos do óleo da sapucainha (Carpotroche brasiliensis Endl, Flacourtiaceae): o primeiro antileprótico usado no Brasil Cyclopentenyl acids from sapucainha oil (Carpotroche brasiliensis Endl, Flacourtiaceae): the first antileprotic used in Brazil
title_short Ácidos ciclopentênicos do óleo da sapucainha (Carpotroche brasiliensis Endl, Flacourtiaceae): o primeiro antileprótico usado no Brasil Cyclopentenyl acids from sapucainha oil (Carpotroche brasiliensis Endl, Flacourtiaceae): the first antileprotic used in Brazil
title_full Ácidos ciclopentênicos do óleo da sapucainha (Carpotroche brasiliensis Endl, Flacourtiaceae): o primeiro antileprótico usado no Brasil Cyclopentenyl acids from sapucainha oil (Carpotroche brasiliensis Endl, Flacourtiaceae): the first antileprotic used in Brazil
title_fullStr Ácidos ciclopentênicos do óleo da sapucainha (Carpotroche brasiliensis Endl, Flacourtiaceae): o primeiro antileprótico usado no Brasil Cyclopentenyl acids from sapucainha oil (Carpotroche brasiliensis Endl, Flacourtiaceae): the first antileprotic used in Brazil
title_full_unstemmed Ácidos ciclopentênicos do óleo da sapucainha (Carpotroche brasiliensis Endl, Flacourtiaceae): o primeiro antileprótico usado no Brasil Cyclopentenyl acids from sapucainha oil (Carpotroche brasiliensis Endl, Flacourtiaceae): the first antileprotic used in Brazil
title_sort ácidos ciclopentênicos do óleo da sapucainha (carpotroche brasiliensis endl, flacourtiaceae): o primeiro antileprótico usado no brasil cyclopentenyl acids from sapucainha oil (carpotroche brasiliensis endl, flacourtiaceae): the first antileprotic used in brazil
publisher Sociedade Brasileira de Química
series Química Nova
issn 0100-4042
1678-7064
publishDate 2009-01-01
description <abstract language="eng">The chaoolmugra oil is one of the oldest medicines used for leprosy until the development of sulfas. In Brazil, it is known as sapucainha oil that is obtained from Carpotroche brasilienesis seeds (Flacourtiaceae). Chemical and medicinal studies of sapucainha oil were introduced in Brazil by Peckolt, Cole and Cardoso which showed that major ciclopentenyl fatty acids as chaulmoogric, hydnocarpic and gorlic were responsible for its bactericidal activity. In this work, a method for quantification of sapucainha oil acidic fraction by HRGC was established using methyl n-heptadecanoate as internal standard. The oil chemical stability was investigated by the use of GC-MS, IR, ¹H and 13C NMR and showed that the main degradation products belong to the cyclopentenyl moiety oxidation.
topic Carpotroche brasiliensis
cyclopentenyl fatty acids
antileprotic
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000100027
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