The Neglected Genes of ALS: Cytoskeletal Dynamics Impact Synaptic Degeneration in ALS

The Neglected Genes of ALS: Cytoskeletal Dynamics Impact Synaptic Degeneration in ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that selectively affects motor neurons (MNs) of the cortex, brainstem, and spinal cord. Several genes have been linked to both familial (fALS) and sporadic (sALS) cases of ALS. Among all the ALS-related genes, a group of genes known...

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Bibliographic Details
Main Authors: María José Castellanos-Montiel, Mathilde Chaineau, Thomas M. Durcan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ALS
ALS2
DCTN1
intermediate filaments
KIF5A
PFN1
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.594975/full

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