Targeting metastatic breast cancer with peptide epitopes derived from autocatalytic loop of Prss14/ST14 membrane serine protease and with monoclonal antibodies

Targeting metastatic breast cancer with peptide epitopes derived from autocatalytic loop of Prss14/ST14 membrane serine protease and with monoclonal antibodies

Abstract Background In order to develop a new immunotherapeutic agent targeting metastatic breast cancers, we chose to utilize autocatalytic feature of the membrane serine protease Prss14/ST14, a specific prognosis marker for ER negative breast cancer as a target molecule. Methods The study was cond...

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Bibliographic Details
Main Authors: Ki Yeon Kim, Minsang Yoon, Youngkyung Cho, Kwang-Hoon Lee, Sora Park, Se-ra Lee, So-Young Choi, Deokjae Lee, Chansik Yang, Eun Hye Cho, Sangjun Davie Jeon, Seok-Hyung Kim, Chungho Kim, Moon Gyo Kim
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Prss14
Metastasis
Immunotherapy
Cancer vaccine
Autocatalytic loop
Online Access:http://link.springer.com/article/10.1186/s13046-019-1373-y

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