Crosslinker concentration controls TGFβ-3 release and annulus fibrosus cell apoptosis in genipin-crosslinked fibrin hydrogels

Crosslinker concentration controls TGFβ-3 release and annulus fibrosus cell apoptosis in genipin-crosslinked fibrin hydrogels

Back pain is a leading cause of global disability associated with intervertebral disc (IVD) pathologies. Discectomy alleviates disabling pain caused by IVD herniation without repairing annulus fibrosus (AF) defects, which can cause accelerated degeneration and recurrent pain. Biological therapies sh...

Full description

Bibliographic Details
Main Authors: CJ Panebianco, TJ DiStefano, B Mui, WW Hom, JC Iatridis
Format: Article
Language:English
Published: AO Research Institute Davos 2020-05-01
Series:European Cells & Materials
Subjects:
intervertebral disc
annulus fibrosus repair
injectable biomaterials
hydrogel
cell delivery
growth factor delivery
fibrin
genipin crosslinking
apoptosis
musculoskeletal tissue engineering.
Online Access:https://www.ecmjournal.org/papers/vol039/pdf/v039a14.pdf

Internet

https://www.ecmjournal.org/papers/vol039/pdf/v039a14.pdf

Similar Items