Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors

Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors

Chronic obstructive pulmonary disease (COPD) represents a worldwide concern with high morbidity and mortality, and is believed to be associated with accelerated ageing of the lung. Alveolar abnormalities leading to emphysema are a key characteristic of COPD. Pulmonary alveolar epithelial type 2 cell...

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Bibliographic Details
Main Authors: Xinhui Wu, Eline M. van Dijk, John-Poul Ng-Blichfeldt, I. Sophie T. Bos, Chiara Ciminieri, Melanie Königshoff, Loes E.M. Kistemaker, Reinoud Gosens
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
chronic obstructive pulmonary disease (copd)
alveolar repair
wnt-5a
wnt-5b
wnt signaling pathway
precision-cut-lung slices (pcls)
lung organoids
Online Access:https://www.mdpi.com/2073-4409/8/10/1147

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