STARD1 Functions in Mitochondrial Cholesterol Metabolism and Nascent HDL Formation. Gene Expression and Molecular mRNA Imaging Show Novel Splicing and a 1:1 Mitochondrial Association

STARD1 Functions in Mitochondrial Cholesterol Metabolism and Nascent HDL Formation. Gene Expression and Molecular mRNA Imaging Show Novel Splicing and a 1:1 Mitochondrial Association

STARD1 moves cholesterol (CHOL) from the outer mitochondrial membrane (OMM) to the inner membrane (IMM) in steroidogenic cells. This activity is integrated into CHOL trafficking and synthesis homeostasis, involving uptake through SR-B1 and LDL receptors and distribution through endosomes, ER, and li...

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Bibliographic Details
Main Authors: Michele Campaigne Larsen, Jinwoo Lee, Joan S. Jorgensen, Colin R. Jefcoate
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Endocrinology
Subjects:
START proteins
cholesterol trafficking
SIK1
CRTC2
nascent HDL formation
sm-FISH
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.559674/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2020.559674/full

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