Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)

Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)

RAS mutation analysis is an important companion diagnostic test. Treatment of colorectal cancer with anti-Epidermal Growth Factor Receptor (EGFR) therapy requires demonstration of RAS mutation status (both KRAS and NRAS), and it is good practice to include BRAF. In Non-Small Cell Lung Cancer (NSCLC)...

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Bibliographic Details
Main Author: Ian A. Cree
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Biomolecular Detection and Quantification
Subjects:
PCR
Cancer
Colorectal
NRAS
KRAS
Lung
Online Access:http://www.sciencedirect.com/science/article/pii/S2214753516300080
Description
Summary:RAS mutation analysis is an important companion diagnostic test. Treatment of colorectal cancer with anti-Epidermal Growth Factor Receptor (EGFR) therapy requires demonstration of RAS mutation status (both KRAS and NRAS), and it is good practice to include BRAF. In Non-Small Cell Lung Cancer (NSCLC) and melanoma, assessment of RAS mutation status can be helpful in triaging patient samples for more extensive testing. This mini-review will discuss the role of PCR methods in providing rapid diagnostic information for cancer patients.
ISSN:2214-7535

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