COMPARATIVE EVALUATION OF PORCINE AND BUFFALO SMALL INTESTINAL SUBMUCOSA FOR THE DEVELOPMENT OF EXTRACELLUALR MATRIX SCAFFOLDS

• Main Authors: V. N. Vasudevan, P. Kuttinarayanan
• Format: Article
• Language: English
• Published: Director of Academics and Research, Kerala Veterinary and Animal Sciences University 2016-07-01
• Series: Journal of Veterinary and Animal Sciences
• Subjects: extracellular matrix scaffolds; small intestinal submucosa; pig; buffalo
• Online Access: https://www.jvas.in/public_html/upload/article_file/article_file_qb2hok.pdf?t=qb2hok

Small intestinal submucosa (SIS) fromc6-8 months old Large White Yorkshire (LWY)cpigs and 18-24 months old buffaloes werecevaluated for the development of extracellularcmatrix scaffolds. The thickness of SIS from buffalo and LWY pigs did not differ significantly.cBuffalo SIS had significantly higherfat and totalccollagen contents, and was more resistantcto collagenase degradation than that fromcLWY pigs, but showed a higher content of acid soluble collagen. Buffalo SIS could be a better raw material for scaffold preparation as it is a widely available low-cost by-product. However, the properties of the scaffold may alter with subsequent treatments like defatting, decellularization, cross linking and sterilization