Effects of α-lipoic acid on oxidative stress, vascular endothelium function and renal function in patients with diabetic nephropathy

• Main Authors: Chun-Mei Qu, Shu-Mei Chen, You-Zhi Zhang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-02-01
• Series: Journal of Hainan Medical University
• Subjects: α-lipoic acid; Diabetic nephropathy; Oxidative stress; Vascular endothelium function; Renal function
• Online Access: http://www.hnykdxxb.com/PDF/201802/06.pdf

Objective: To investigate the effects of 毩-lipoic acid on oxidative stress, vascular endothelium function and renal function in diabetic nephropathy patients. Methods: According to random data table method, a total of 80 patients with diabetic nephropathy from September 2016 to August 2017 were divided into observation group and control group (n=40). The patients of control group were treated with routine therapy while the patients of observation group were given intravenous infusion of 毩-lipoic acid on the basis of conventional therapy. The levels of oxidative stress, vascular endothelium function and renal function changes were compared between the two groups before and after the treatment. Results: The levels of SOD, MDA, NO, ET-1, RBP and CysC in the two groups before treatment were not statistically significant. Compared with the levels before treatment, the level of SOD in the observation group was significantly increased and the level of MDA was significantly decreased; the level of SOD in the observation group was significantly higher than that in the control group, and the level of MDA was significantly lower than that of the control group; the above differences were statistically significant. The levels of SOD and MDA had no significant changes in the control group before and after treatment. After treatment, the levels of ET-1, RBP and CysC in the two groups were significantly lower than those in the same group before treatment, and the observation group levels were significantly lower than those in the control group; the levels of NO in the two groups after treatment were significantly higher than those in the same group before treatment, and the observation group was significantly higher than that of the control group; the above differences were statistically significant. Conclusions: On the basis of conventional treatment, combining with 毩-lipoic acid can better reduce the level of oxidative stress, improve vascular endothelial function, renal function in patients with diabetic nephropathy, which has an important clinical value.