Minocycline treatment ameliorates interferon-alpha-induced neurogenic defects and depression-like behaviors in mice

Minocycline treatment ameliorates interferon-alpha-induced neurogenic defects and depression-like behaviors in mice

Interferon-alpha (IFN-α) is a proinflammatory cytokine that is widely used for the treatment of chronic viral hepatitis and malignancy, because of its immune-activating, antiviral, and antiproliferative properties. However, long-term IFN-α treatment frequently causes depression, which limits its cli...

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Bibliographic Details
Main Authors: Lian-Shun eZheng, Naoko eKaneko, Kazunobu eSawamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Depression
Hippocampus
Microglia
Neurogenesis
interferon
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00005/full

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