In adenosine A2B knockouts acute treatment with inorganic nitrate improves glucose disposal, oxidative stress and AMPK signaling in the liver

In adenosine A2B knockouts acute treatment with inorganic nitrate improves glucose disposal, oxidative stress and AMPK signaling in the liver

Rationale: Accumulating studies suggest that nitric oxide (NO) deficiency and oxidative stress are central pathological mechanisms in type 2 diabetes. Recent findings demonstrate therapeutic effects by boosting a nitrate-nitrite-NO pathway, an alternative pathway for NO formation. This study aimed a...

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Bibliographic Details
Main Authors: Maria ePeleli, Michael eHezel, Christa eZollbrecht, A. Erik G Persson, Jon O Lundberg, Eddie eWeitzberg, Bertil B Fredholm, Mattias eCarlstrom
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Physiology
Subjects:
Insulin Resistance
NADPH Oxidase
Nitric Oxide
Obesity
metabolic syndrome
superoxide
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00222/full

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