Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells

Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells

Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocy...

Full description

Bibliographic Details
Main Authors: Maria Lehene, Eva Fischer-Fodor, Florina Scurtu, Niculina D. Hădade, Emese Gal, Augustin C. Mot, Alina Matei, Radu Silaghi-Dumitrescu
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceuticals
Subjects:
hemoglobin
albumin
ascorbate
erythrocyte
antioxidant
leukocyte
Online Access:https://www.mdpi.com/1424-8247/13/6/107
Description
Summary:Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological stress agent.
ISSN:1424-8247

Similar Items