Pre-clinical and Clinical Implications of “Inside-Out” vs. “Outside-In” Paradigms in Multiple Sclerosis Etiopathogenesis

Pre-clinical and Clinical Implications of “Inside-Out” vs. “Outside-In” Paradigms in Multiple Sclerosis Etiopathogenesis

Multiple Sclerosis (MS) is an immune-mediated neurological disorder, characterized by central nervous system (CNS) inflammation, oligodendrocyte loss, demyelination, and axonal degeneration. Although autoimmunity, inflammatory demyelination and neurodegeneration underlie MS, the initiating event has...

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Bibliographic Details
Main Authors: Haley E. Titus, Yanan Chen, Joseph R. Podojil, Andrew P. Robinson, Roumen Balabanov, Brian Popko, Stephen D. Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
multiple sclerosis
etiopathogenesis
demyelination
autoimmunity
animal models
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.599717/full

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