Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids

Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids

A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under...

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Main Authors: Ran Xia, Mingwei Geng, Haiming Guo, Zhiguang Zhang, Guirong Qu
Format: Article
Language:English
Published: MDPI AG 2007-03-01
Series:Molecules
Subjects:
Modified nucleoside analogues
microwave irradiation
peptide nucleic acids
Online Access:http://www.mdpi.com/1420-3049/12/3/543/
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spelling doaj-1aa95f58a0bc48fa94ca70be73ef141b2020-11-25T01:29:49ZengMDPI AGMolecules1420-30492007-03-0112354355110.3390/12030543Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic AcidsRan XiaMingwei GengHaiming GuoZhiguang ZhangGuirong QuA simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation.http://www.mdpi.com/1420-3049/12/3/543/Modified nucleoside analoguesmicrowave irradiationpeptide nucleic acids
collection DOAJ
language English
format Article
sources DOAJ
author Ran Xia
Mingwei Geng
Haiming Guo
Zhiguang Zhang
Guirong Qu
spellingShingle Ran Xia
Mingwei Geng
Haiming Guo
Zhiguang Zhang
Guirong Qu
Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids
Molecules
Modified nucleoside analogues
microwave irradiation
peptide nucleic acids
author_facet Ran Xia
Mingwei Geng
Haiming Guo
Zhiguang Zhang
Guirong Qu
author_sort Ran Xia
title Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids
title_short Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids
title_full Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids
title_fullStr Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids
title_full_unstemmed Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids
title_sort microwave-promoted facile and efficient preparation of n-(alkoxycarbonylmethyl) nucleobases ã¢âˆâ’ building blocks for peptide nucleic acids
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2007-03-01
description A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation.
topic Modified nucleoside analogues
microwave irradiation
peptide nucleic acids
url http://www.mdpi.com/1420-3049/12/3/543/
work_keys_str_mv AT ranxia microwavepromotedfacileandefficientpreparationofnalkoxycarbonylmethylnucleobasesaaˆabuildingblocksforpeptidenucleicacids
AT mingweigeng microwavepromotedfacileandefficientpreparationofnalkoxycarbonylmethylnucleobasesaaˆabuildingblocksforpeptidenucleicacids
AT haimingguo microwavepromotedfacileandefficientpreparationofnalkoxycarbonylmethylnucleobasesaaˆabuildingblocksforpeptidenucleicacids
AT zhiguangzhang microwavepromotedfacileandefficientpreparationofnalkoxycarbonylmethylnucleobasesaaˆabuildingblocksforpeptidenucleicacids
AT guirongqu microwavepromotedfacileandefficientpreparationofnalkoxycarbonylmethylnucleobasesaaˆabuildingblocksforpeptidenucleicacids
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