Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids

Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids

A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under...

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Bibliographic Details
Main Authors: Ran Xia, Mingwei Geng, Haiming Guo, Zhiguang Zhang, Guirong Qu
Format: Article
Language:English
Published: MDPI AG 2007-03-01
Series:Molecules
Subjects:
Modified nucleoside analogues
microwave irradiation
peptide nucleic acids
Online Access:http://www.mdpi.com/1420-3049/12/3/543/
Description
Summary:A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation.
ISSN:1420-3049

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