Dietary Omega-3 Polyunsaturated Fatty Acid Deprivation Does Not Alter Seizure Thresholds but May Prevent the Anti-seizure Effects of Injected Docosahexaenoic Acid in Rats

Dietary Omega-3 Polyunsaturated Fatty Acid Deprivation Does Not Alter Seizure Thresholds but May Prevent the Anti-seizure Effects of Injected Docosahexaenoic Acid in Rats

Background: Brain concentrations of omega-3 docosahexaenoic acid (DHA, 22:6n-3) have been reported to positively correlate with seizure thresholds in rodent seizure models. It is not known whether brain DHA depletion, achieved by chronic dietary omega-3 polyunsaturated fatty acid (PUFA) deficiency,...

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Bibliographic Details
Main Authors: Ameer Y. Taha, Marc-Olivier Trepanier, Flaviu A. Coibanu, Anjali Saxena, Melanie A. Jeffrey, Nadeen M. Y. Taha, W. McIntyre Burnham, Richard P. Bazinet
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Neurology
Subjects:
after-discharge seizure threshold
amygdala
pentylenetetrazol
omega-3 deficiency
DHA
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.01188/full

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