BMP-9 Modulates the Hepatic Responses to LPS

BMP-9 Modulates the Hepatic Responses to LPS

It was previously shown that Bone Morphogenetic Protein (BMP)-9 is constitutively produced and secreted by hepatic stellate cells (HSC). Upon acute liver damage, BMP-9 expression is transiently down-regulated and blocking BMP-9 under conditions of chronic damage ameliorated liver fibrogenesis in C57...

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Bibliographic Details
Main Authors: Haristi Gaitantzi, Julius Karch, Lena Germann, Chen Cai, Vanessa Rausch, Emrullah Birgin, Nuh Rahbari, Tatjana Seitz, Claus Hellerbrand, Courtney König, Hellmut G. Augustin, Carolin Mogler, Carolina de la Torre, Norbert Gretz, Timo Itzel, Andreas Teufel, Matthias P. A. Ebert, Katja Breitkopf-Heinlein
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
lps
bmp-9
hsc
lsec
kupffer cells
liver
capillarization
il-6
macrophages
myofibroblasts
Online Access:https://www.mdpi.com/2073-4409/9/3/617

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