Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

Differential inhibitor sensitivity between human kinases VRK1 and VRK2.

Human vaccinia-related kinases (VRK1 and VRK2) are atypical active Ser-Thr kinases implicated in control of cell cycle entry, apoptosis and autophagy, and affect signalling by mitogen activated protein kinases (MAPK). The specific structural differences in VRK catalytic sites make them suitable cand...

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Bibliographic Details
Main Authors: Marta Vázquez-Cedeira, Iria Barcia-Sanjurjo, Marta Sanz-García, Ramiro Barcia, Pedro A Lazo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3150407?pdf=render

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