Association between Myocardial Infarction and Periodontitis: a Meta-Analysis of Case-Control Studies

AbstractBackground and Objective: Many clinical researches have been carried out to investigate the relationship between myocardial infarction (MI) and periodontitis. Despite most of them indicated that the periodontitis may be associated with an increased risk of MI, the findings and study types of...

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Main Authors: Quan Shi, Bin Zhang, Na Huo, Chuan Cai, Hongchen Liu, Juan Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00519/full
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spelling doaj-1a9ca191521443f7928d9efb19736afb2020-11-24T23:44:10ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2016-11-01710.3389/fphys.2016.00519231475Association between Myocardial Infarction and Periodontitis: a Meta-Analysis of Case-Control StudiesQuan Shi0Bin Zhang1Na Huo2Chuan Cai3Hongchen Liu4Juan Xu5Chinese PLA General HospitalChinese PLA General HospitalChinese PLA General HospitalChinese PLA General HospitalChinese PLA General HospitalChinese PLA General HospitalAbstractBackground and Objective: Many clinical researches have been carried out to investigate the relationship between myocardial infarction (MI) and periodontitis. Despite most of them indicated that the periodontitis may be associated with an increased risk of MI, the findings and study types of these studies have been inconsistent. The goal of this meta-analysis was to critically assess the strength of the association between MI and periodontitis in case-control studies.Methods: PubMed and the Cochrane Library were searched for eligible case-control studies reporting relevant parameters that compared periodontal status between MI and control subjects. The odds ratios (ORs) and 95% confidence intervals (CIs) from each study were pooled to estimate the strength of the association between MI and periodontitis. The mean differences and 95% CIs for periodontal-related parameters were calculated to determine their overall effects.Results: Seventeen studies including a total of 3456 MI patients and 3875 non-MI control subjects were included. The pooled OR for the association between MI and periodontitis was 2.531 (95% CI: 1.927-3.324). The mean differences (95% CIs) for clinical attachment loss, probing depth, bleeding on probing, plaque index, and the number of missing teeth were 1.000 (0.726-1.247), 1.209 (0.538-1.880), 0.342 (0.129-0.555), 0.383 (0.205-0.560), and 4.122 (2.012-6.232), respectively. Conclusion: With the current evidence, the results support the presence of a significant association between MI and periodontitis. Moreover, MI patients had worse periodontal and oral hygiene status and fewer teeth than did control subjects. More high-quality and well-designed studies focusing on the casual relationship between MI and periodontitis should be conducted in the future.http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00519/fullMyocardial InfarctionPeriodontitisMeta-analysiscase-control studyrisk factorPeriodontal examination
collection DOAJ
language English
format Article
sources DOAJ
author Quan Shi
Bin Zhang
Na Huo
Chuan Cai
Hongchen Liu
Juan Xu
spellingShingle Quan Shi
Bin Zhang
Na Huo
Chuan Cai
Hongchen Liu
Juan Xu
Association between Myocardial Infarction and Periodontitis: a Meta-Analysis of Case-Control Studies
Frontiers in Physiology
Myocardial Infarction
Periodontitis
Meta-analysis
case-control study
risk factor
Periodontal examination
author_facet Quan Shi
Bin Zhang
Na Huo
Chuan Cai
Hongchen Liu
Juan Xu
author_sort Quan Shi
title Association between Myocardial Infarction and Periodontitis: a Meta-Analysis of Case-Control Studies
title_short Association between Myocardial Infarction and Periodontitis: a Meta-Analysis of Case-Control Studies
title_full Association between Myocardial Infarction and Periodontitis: a Meta-Analysis of Case-Control Studies
title_fullStr Association between Myocardial Infarction and Periodontitis: a Meta-Analysis of Case-Control Studies
title_full_unstemmed Association between Myocardial Infarction and Periodontitis: a Meta-Analysis of Case-Control Studies
title_sort association between myocardial infarction and periodontitis: a meta-analysis of case-control studies
publisher Frontiers Media S.A.
series Frontiers in Physiology
issn 1664-042X
publishDate 2016-11-01
description AbstractBackground and Objective: Many clinical researches have been carried out to investigate the relationship between myocardial infarction (MI) and periodontitis. Despite most of them indicated that the periodontitis may be associated with an increased risk of MI, the findings and study types of these studies have been inconsistent. The goal of this meta-analysis was to critically assess the strength of the association between MI and periodontitis in case-control studies.Methods: PubMed and the Cochrane Library were searched for eligible case-control studies reporting relevant parameters that compared periodontal status between MI and control subjects. The odds ratios (ORs) and 95% confidence intervals (CIs) from each study were pooled to estimate the strength of the association between MI and periodontitis. The mean differences and 95% CIs for periodontal-related parameters were calculated to determine their overall effects.Results: Seventeen studies including a total of 3456 MI patients and 3875 non-MI control subjects were included. The pooled OR for the association between MI and periodontitis was 2.531 (95% CI: 1.927-3.324). The mean differences (95% CIs) for clinical attachment loss, probing depth, bleeding on probing, plaque index, and the number of missing teeth were 1.000 (0.726-1.247), 1.209 (0.538-1.880), 0.342 (0.129-0.555), 0.383 (0.205-0.560), and 4.122 (2.012-6.232), respectively. Conclusion: With the current evidence, the results support the presence of a significant association between MI and periodontitis. Moreover, MI patients had worse periodontal and oral hygiene status and fewer teeth than did control subjects. More high-quality and well-designed studies focusing on the casual relationship between MI and periodontitis should be conducted in the future.
topic Myocardial Infarction
Periodontitis
Meta-analysis
case-control study
risk factor
Periodontal examination
url http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00519/full
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